SyncleFluor™
Fluorescent Synthetic Vesicles
MULTICOLOR
Choose from 7 different fluorophores (ranging from UV to NIR) to match your excitation and emission needs.
UNIFORM
Meticulously engineered to be monodisperse, ensuring uniform size and number of fluorophores/particle.
SyncleFluor™ is room-temperature stable unlike traditional lipid-based vesicle reference materials.
STABLE
NO PREP
No reconstitution or aliquoting needed. Simply dilute to your desired concentration and use.
ROBUST
Fluorophores covalently attached to individual vesicles to ensure zero leaching over time.
Key Features & Real-World Data
Full Color Spectrum
01
Seamlessly integrate SyncleFluor™ into your workflow with 7 available colors, from ultraviolet (UV) to near-infrared (NIR).
Our product range covers all excitation lasers and fluorescence detectors found in common nanoparticle analyzers including flow cytometers and nanoparticle tracking analysis (NTA) systems.
Monodisperse
02
Drive data reproducibility with SyncleFluor™.
These vesicles deliver precise, consistent sizing independent of fluorophore choice.
All variants feature a narrow size distribution and an excellent polydispersity index (PDI < 0.05).
SyncleFluor™ is available now in 135 nm, with more options in development to support your future needs.
Homogeneous brightness
03
SyncleFluor™ delivers exceptional particle-to-particle consistency through a uniform distribution of fluorophores that minimizes population variability. Flow cytometry analysis confirms a single fluorescence population with a narrow fluorescence intensity distribution and the absence of unlabelled particles.
Additionally, SyncleFluor™ boasts a brightness that resembles real-world nanoparticles, unlike traditional fluorescent beads which are often too bright to be a suitable standard.
Zero dye leaching
04
Our proprietary process tags fluorophores directly onto SyncleFluor™. This creates a highly stable linkage that eliminates dye leaching and fluorescence fluctuations during storage and use.
Overlaid excitation and emission spectra of SyncleFluor™ variants.
(Left) Representative TEM image and (right) overlaid DLS data of SyncleFluor™ variants acquired on a Malvern Zetasizer Ultra Red.
Nano-flow cytometry data of SyncleFluor™ 670 (R), 135 nm
acquired on a Beckman Coulter CytoFlex Nano
Negative controls, including buffer only (PBS) and SyncleRef™ 135 nm (same-sized, non-fluorescent synthetic vesicles) collected on the same instrument with identical gains/thresholds.
Photograph of SyncleFluor™ under UV illumination
