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Our Technology

Pioneering the next generation of nanoparticle standards with Syncles™

Electron microscopy image of Syncles™

Cryo-TEM image of synthetic vesicles called Syncles, revealing its membrane and hollow core structure.

Schematic representation of Syncles™

A schematic representation of Syncles highlight its membrane-bound structure encapsulating an inner aqueous core.

Membrane Structure

Hollow Interior

Syncles™, short for synthetic vesicles, are hollow nanoparticles with a membrane structure. They are synthetic analogs of lipid vesicles (liposomes), which represent the largest class of FDA-approved nanoparticles in clinical use today. Syncles™ are produced using Vesiculate's proprietary technology.

What makes Syncles™ Unique?

The first commercially available synthetic (non-lipid) vesicle standards

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Nanoscale Precision

Engineered with sub-200 nm sizes and unprecedented uniformity vs other commercial standards.

Unmatched Stability

Withstands environmental and storage conditions that typically degrade lipid-based vesicles.

Structurally Versatile

Configurable size, chemistry, and surface properties to meet your specific needs.

Broad Applications

Use in applications ranging from life science to materials science.

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Cartoon schematic comparing Syncles to liposomes.

Syncles™

Liposomes

Synthetic
Membrane

Lipid
Membrane

Advantages of Syncles™

Ready to Use
Zero sample prep. Skip reconstitution and aliquoting as typically needed with lipid-based standards. Simply dilute Syncles™ and use directly.
Room-Temp Stable
Stable at room temp for extended periods of time. Avoid deterioration risks common with lipid-based vesicles.
Excellent Compatibility
Compatible with various buffers, pH levels, and organic solvents. Significantly more robust than lipid-based vesicles.
Monodisperse by Design
Unprecedented uniformity in particle size distribution.
Lot-to-Lot Consistency
Proprietary manufacturing ensures excellent reproducibility between lots.
Broad Applications
Go beyond simple calibration.
Use as model nanoparticles for analytical development or assays.

Learn More About Syncles™ 

3D visualization of nanoparticle analysis optimization, showing the transition from blurry, inconsistent data to sharp, standardized results.

Challenges in
Nanoparticle Analysis

Learn why standards like Syncles™ are crucial in nanoparticle analysis.

A row of Vesiculate's Syncle™ product tubes with color-coded caps representing the SyncleRef™ and SyncleFluor™ product lines.

Explore Syncle™ Products

Ready to find the right standard for your specific application?

Contact Us

Nature of inquiry

Have questions or need further technical details? Please reach out to us using this form.

We welcome all discussions.

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